sodium glycodeoxycholic acid (gdx) (Merck KGaA)
90
Structured Review
Merck KGaA
sodium glycodeoxycholic acid (gdx)
Sodium Glycodeoxycholic Acid (Gdx), supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sodium+glycodeoxycholic+acid+(gdx)/sodium+glycodeoxycholic+acid++gdx+/pm33450318-80-0-7
Average 90 stars, based on 1 article reviews
Sodium Glycodeoxycholic Acid (Gdx), supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sodium+glycodeoxycholic+acid+(gdx)/sodium+glycodeoxycholic+acid++gdx+/pm33450318-80-0-7
Average 90 stars, based on 1 article reviews
sodium glycodeoxycholic acid (gdx) - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids. Article Snippet: In this study, we use molecular dynamics (MD) and experimental techniques (nephelometry and dynamic light scattering) to investigate the influence of cholesterol content and pH on the colloidal structures that form in the gastrointestinal (GI) tract upon lipid digestion.. We demonstrate that the ionization state of the molecular species is a primary driver for the selfassembly of aggregates formed by model bile and therefore should be considered when performing in silico modeling of colloidal drug delivery systems.. Additionally, the incorporation of physiological concentrations of cholesterol within the model systems does not affect size, number, shape, or dynamics of the aggregates to a significant degree. Article Title: Interaction with biliary and pancreatic fluids drives supersaturation and drug absorption from lipid-based formulations of low (saquinavir) and high (fenofibrate) permeability poorly soluble drugs. Article Snippet: Drug absorption from lipid-based formulations (LBFs) in the gastrointestinal (GI) tract is the result of a series of processes, including formulation dispersion, interaction with biliary and pancreatic secretions, drug solubilisation and supersaturation, and finally intestinal permeability.. Optimal formulation design is dependent on a good understanding of the limitations to, and drivers of, absorption, but for LBFs the complexity of these processes makes data interpretation complex.. The current study has re-examined a previous in vitro digestion–in situ perfusion model to increase physiological relevance and has used this model to examine drug absorption from LBFs. |